Lip volumization with cross-linked hyaluronic acid 18 mg/ml. Efficacy and safety in 102 treated patients
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Título
Lip volumization with cross-linked hyaluronic acid 18 mg/ml. Efficacy and safety in 102 treated patients
Descripción
Introduction: beauty trends have increased the demand for aesthetic procedures, especially the use of hyaluronic acid (HA), to rejuvenate the face and enhance lips. This safe and effective treatment hydrates, fills wrinkles, and restores volume to different areas of the face. HA is obtained from non-animal sources, is non-immunogenic, and possesses antioxidant properties. The perioral region, key to facial aging, is highly sought after for correcting wrinkles, folds, and the loss of definition caused by factors such as age, sun exposure, and lifestyle habits. Cross-linked hyaluronic acid (HRA) is an ideal option for restoring volume to this area.
Objectives: to evaluate the safety, efficacy and adverse effects of using HRA 18 mg/ml as a lip filler.
Materials and methods: a prospective clinical study included 102 patients (81 women and 21 men), aged 25–65, who required lip volumization and received Cientific Hyaluronic Facial Implant 18® (HRA 18 mg/ml). Treatment efficacy was assessed using the Global Aesthetic Improvement Scale (GAIS). Initial lip volume and perioral wrinkle severity were assessed using the photonumeric scales MERZ (Merz Lip Fullness Scale, MLFS) and Wrinkle Severity Rating Scale (WSRS), respectively. Safety was determined by analyzing local reactions at the injection site and the occurrence of adverse events. The product was administered at a dose of up to 1 ml per half of the lip in an initial application (T0), with follow-ups at 1, 3, and 8 months. If necessary, a single reapplication was performed during these follow-ups. Treatment efficacy was assessed at a final follow-up at 12 months.
Results: adverse effects were mild, of immediate onset, common for this type of treatment, which resolved without the need for special treatment. The volumizing effect of HRA 18 mg/ml was effective in 98% of treated patients, with a gradual decrease after 12 months. A significant improvement in lip hydration and firmness was observed.
Conclusions: HRA 18 mg/ml is a safe and effective treatment as a dermal filler in lips, with high volume retention and lasting up to 12 months. Patients and professionals experienced high satisfaction, and improvements in skin firmness and elasticity were observed. The results support HRA as a viable and beneficial option in aesthetic medicine.
Objectives: to evaluate the safety, efficacy and adverse effects of using HRA 18 mg/ml as a lip filler.
Materials and methods: a prospective clinical study included 102 patients (81 women and 21 men), aged 25–65, who required lip volumization and received Cientific Hyaluronic Facial Implant 18® (HRA 18 mg/ml). Treatment efficacy was assessed using the Global Aesthetic Improvement Scale (GAIS). Initial lip volume and perioral wrinkle severity were assessed using the photonumeric scales MERZ (Merz Lip Fullness Scale, MLFS) and Wrinkle Severity Rating Scale (WSRS), respectively. Safety was determined by analyzing local reactions at the injection site and the occurrence of adverse events. The product was administered at a dose of up to 1 ml per half of the lip in an initial application (T0), with follow-ups at 1, 3, and 8 months. If necessary, a single reapplication was performed during these follow-ups. Treatment efficacy was assessed at a final follow-up at 12 months.
Results: adverse effects were mild, of immediate onset, common for this type of treatment, which resolved without the need for special treatment. The volumizing effect of HRA 18 mg/ml was effective in 98% of treated patients, with a gradual decrease after 12 months. A significant improvement in lip hydration and firmness was observed.
Conclusions: HRA 18 mg/ml is a safe and effective treatment as a dermal filler in lips, with high volume retention and lasting up to 12 months. Patients and professionals experienced high satisfaction, and improvements in skin firmness and elasticity were observed. The results support HRA as a viable and beneficial option in aesthetic medicine.
Autor
Claudio Dachevsky
Fecha
12/05/2025
Colaborador
Allanmar
Identificador
Hyperlink Item Type Metadata
Citación
Claudio Dachevsky, “Lip volumization with cross-linked hyaluronic acid 18 mg/ml. Efficacy and safety in 102 treated patients,” Sello Editorial Lugones, consulta 30 de julio de 2025, https://ciencia.lugoneseditorial.com.ar/items/show/36.