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              <text>&lt;a href="https://lugoneseditorial.com.ar/novedades/dermatologia/hidroxiapatita-calcio/"&gt;https://lugoneseditorial.com.ar/novedades/dermatologia/hidroxiapatita-calcio/&lt;/a&gt;</text>
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                <text>Evaluation of 80 mg/ml calcium hydroxyapatite in the treatment of nasolabial folds. Analysis of durability, safety, and efficacy at 12 months</text>
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                <text>Introduction: skin   aging   involves   collagen   fragmentation,   which   affects   the   extracellular  matrix  and  accelerates  deterioration.  Photoaging,  caused  by  ultraviolet    radiation,  motivates  patients  to  seek  corrective  treatments.  Calcium  hydroxyapatite  (CaHA) is a biocompatible filler that stimulates collagen production and provides safe and long-lasting results with a low complication rate. Correction of the nasolabial fold (NLF) is key to facial aesthetics, and CaHA has been shown to be effective in improving appearance and rejuvenating the face.&#13;
&#13;
Objectives: demonstrate the efficacy and safety of Cientific Permanent Facial Implant II® (CaHA 80 mg/ml) for the correction of mild to moderate NLF.1&#13;
&#13;
Materials and methods: a multicenter, prospective, open-label, longitudinal clinical study included 122 patients of both sexes (35–65 years old) with mild to moderate nasolabial folds (NLF). A maximum of 1 ml of CaHA filler was applied per fold, with the possibility of reapplication after 9 months in selected cases clinical parameters of  efficacy,  safety,  and  duration  of  effect  were  assessed  using  validated  scales  at  baseline and at 3, 6, 9, and 12 months. The Lemperle scale was used for the initial patient assessment, and improvements were also assessed using this scale and the Global Aesthetic Improvement Scale (GAIS) and photographs of each follow-up.&#13;
&#13;
Results:  the  study  confirmed  the  safety  and  efficacy  of  Cientific  Permanent  Facial  Implant II® (CaHA 80 mg/ml) for the correction of NLF, with mild adverse events such as pain, erythema, edema and ecchymosis, all transient and resolved spontaneously. At 12 months, the majority of patients maintained satisfactory results, with a high rate of improvement according to the GAIS scale. Only two patients were evaluated outside the protocol for asymmetries, and only one required correction. All participants attended the established follow-up visits, demonstrating adherence to the study and stability of the treatment.&#13;
&#13;
Conclusions: Cientific Permanent Facial Implant II® (CaHA 80 mg/ml) was shown to  be  an  effective  and  safe  treatment  for  the  correction  of  mild  to  moderate  NLF.  Reapplication after 9 months optimizes the duration of the effect in certain patients</text>
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                <text>Ivanna Laura Salerno, Plastic Surgeon, Director of the Dr. Ivanna Salerno Center, City of Buenos Aires, Argentina. ORCID: &lt;a href="https://orcid.org/0009-0004-5430-5683"&gt;https://orcid.org/0009-0004-5430-5683&lt;/a&gt; Claudio Dachevsky, Plastic Surgeon, General Manager, Lipo Plastic Surgery Clinic, São Paulo, Brazil. ORCID: &lt;a href="https://orcid.org/0009-0006-5400-0585"&gt;https://orcid.org/0009-0006-5400-0585&lt;/a&gt;</text>
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                <text>Cientific Permanent Facial Implant II® </text>
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                <text>Cientific  Permanent  Facial  Implant  II®</text>
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                <text>&lt;a href="https://doi.org/10.47196/0596"&gt;https://doi.org/10.47196/0596&lt;/a&gt;</text>
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              <text>&lt;a href="https://lugoneseditorial.com.ar/novedades/dermatologia/acido-hialuronico-nasolabiales/"&gt;https://lugoneseditorial.com.ar/novedades/dermatologia/acido-hialuronico-nasolabiales/&lt;/a&gt;</text>
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                <text>Evaluation of the efficacy and safety of cross-linked hyaluronic acid&#13;
30 mg/ml for filling nasolabial folds</text>
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                <text>Introduction: the nasolabial folds (NLF) are a highly mobile facial region that undergoes multifactorial changes during aging. Cientific Hyaluronic Facial Implant 30® is a 30 mg/ml cross-linked hyaluronic acid (HRA) filler developed to optimize the results of this highly dynamic facial area.&#13;
&#13;
Objectives: to evaluate the safety and efficacy of Cientific Hyaluronic Facial Implant 30® (CH30), composed of 30 mg/ml HRA, for the correction of moderate to severe NLF.&#13;
&#13;
Materials and methods: a 12-month, prospective, multicenter clinical study that included 64 male and female patients between 30 and 75 years of age with moderate to severe NLF treated in both NLFs with CH30 to balance the asymmetry until optimal correction was achieved. Efficacy assessments by evaluators included analysis of NLF severity using the Wrinkle Severity Rating Scale (WSRS) and improvement using the Global Aesthetic Improvement Scale (GAIS). Safety was recorded throughout the study based on checks at each appointment and patient reporting of adverse events.&#13;
&#13;
Results: no adverse events were observed during the 12-month follow-up. In 100% of cases, defect correction, duration, and satisfaction were rated by patients and physicians as “improved” to “very improved,” with a very slow decrease in effect observed at 12 months.&#13;
&#13;
Conclusions: the use of AHR for the treatment of NLF is one of the most effective and safe options in current aesthetic medicine. Its ability to restore volume, smooth wrinkles, and improve skin quality make it a key tool for facial rejuvenation. The durability of the results, combined with its low complication rate, makes HRA widely recommended for patients seeking a natural and longlasting aesthetic improvement, making it one of the most popular interventions in modern aesthetic medicine.</text>
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                <text>Claudio Dachevsky: Plastic Surgeon, General Manager, Lipo Plastic Surgery Clinic, São Paulo, Brazil</text>
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                <text>I.  Russell-Goldman E, Murphy GF. The pathobiology of skin aging. New insights into an old dilemma. Am J Pathol 2020 Jul;190(7):1356-1369. doi: 10.1016/j. ajpath.2020.03.007. &#13;
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II.  Lupo M. Hyaluronic acid fillers in facial rejuvenation. Seminars in cutaneous medicine and surgery 2006; 25:122-6. doi: 10.1016/j.sder.2006.06.011. &#13;
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III.  Duranti F, Salti G, Bovani B, Calandra M, Rosati ML. Injectable hyaluronic acid gel for soft tissue augmentation. A clinical and histological study. Dermatol Surg 1998 Dec;24(12):1317-25. doi: 10.1111/ j.1524-4725.1998.tb00007.x. &#13;
&#13;
IV.  Braccini F, Fanian F, García P, et al Comparative clinical study for the efficacy and safety of two different hyaluronic acid-based fillers with Tri-Hyal versus Vycross technology. A long-term prospective&#13;
randomized clinical trial. J Cosmet Dermatol 2023. Feb;22(2):473-485. doi: 10.1111/jocd.15200. &#13;
&#13;
V.  Peña F. Factores relacionados a la durabilidad del ácido hialurónico reticulado. Rev Facultad de Medicina de la Universidad de lberoamérica 2023;2;13-21. doi 10.54376/rcmui.v2i2.148.&#13;
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VI.  Wongprasert P, Dreiss CA, Murray G. Evaluating hyaluronic acid dermal fillers. A critique of current characterization methods. Dermatol Ther 2022 Jun;35(6):e15453. doi: 10.1111/dth.15453. &#13;
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VII.  Sánchez-Carpintero D, Ruiz-Rodríguez R. Materiales de relleno: tipos, indicaciones y complicaciones. Actas Dermosifiliogr 2010;101(5):381-393.&#13;
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VIII.  Bukhari SNA, Roswandi NL, Waqas M, Habib H, Hussain F, et al. Hyaluronic acid, a promising skin rejuvenating biomedicine. A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 2018 Dec;120(Pt B):1682-1695. doi: 10.1016/j. ijbiomac.2018.09.188. &#13;
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IX.  Martínez-Carpio PA, Vega López PM. Materiales de relleno temporales en medicina estética: revisión de la literatura sobre la incidencia de efectos adversos y complicaciones. Medicina Estética 2019;59(2):14-19. doi: 10.48158/MedicinaEstetica.059.02 &#13;
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X.  Cifuentes-Mimoso T, Signes-Soler F. Estudio de efectos adversos tras tratamiento con implantes cutáneos  de ácido hialurónico. Universitat Autonoma de Barcelona. Disponible en: https://semcc.com/master/files/Hialuronico%20y%20efectos%20adversos%20-%20Dras.%20Cifuentes%20y%20Signes.pdf.&#13;
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XI.  Robles M. Estudio de seguridad y eficacia del ácido hialurónico reticulado en relleno de surcos nasolabiales. doi: 10.47196/0573.&#13;
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XII.  Bogdan-Allemann I, Baumann L. Hyaluronic acid gel (Juvéderm) preparations in the treatment of facial wrinkles and folds. Clin Interv Aging 2008;3(4):629-34. Doi: 10.2147/cia.s3118.&#13;
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XIII.  Jordan DR. Delayed inflammatory reaction to hyaluronic acid (Restylane). Ophthalmic Plast Reconstr Surg 2005 Sep;21(5):401-2. doi: 10.1097/01.iop.0000173194.18050.b8. &#13;
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XIV.  NASHATM. The monograpf. Disponible en: https://es.scribd.com/document/507252742/Monograph-ofNASHA.&#13;
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XV.  Cornejo P, Alcolea JM, Trelles MA. Perspectivas en el uso de materiales de relleno inyectables para tejidos blandos, desde nuestra experiencia. 1º parte. Cir Plast Iberolatinoam 2011;37(4):393-402. doi: 10.4321/S037678922011000400013.&#13;
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XVI.  Day D, Littler C, Swift R, Gottlieb S. The Wrinkle Severity&#13;
Scale. American Journal of Clinical Dermatology 2004;5:49-52. doi: 10.2165/00128071-200405010-00007. &#13;
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XVII.  Dibernardo G, DiBernardo B. Prediction of treatment outcomes for neck rejuvenation Utilizing a unique classification system of treatment approach using a 1440-nm side-firing laser. Aesthetic Surgery Journal 2018;38:S43-S51. doi:10.1093/asj/sjy066. &#13;
Ther 2022&#13;
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XVIII.  Sundaram H, Shamban A, Schlessinger J, Kaufman. Janette&#13;
J, Joseph, JH, Lupin M, Draelos Z, Carey W, Smith S, Eaton L. Efficacy&#13;
and safety of a new resilient hyaluronic acid filler in the correction&#13;
of moderateto-severe dynamic perioral rhytides. A 52-week prospective, multicenter, controlled, randomized, evaluator-blinded&#13;
study. Dermatol Surg. 2022 Jan 1;48(1):87-93. doi: 10.1097/DSS.0000000000003238.&#13;
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XIX.  Abduljabbar MH, Basendwh MA. Complications of hyaluronic acid fillers and their managements. Journal of Dermatology &amp; Dermatologic Surgery 2016;20(2). doi: 10.1016/j.jdds.2016.01.001.&#13;
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XX.  Instrucciones de uso del producto Cientific Hyaluronic Facial Implant 30. Disponible en: https://es.scribd.com/document/265233528/Cientific-Hyaluronic-FacialImplant-30y18.&#13;
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XXI.  Kaufman-Janette J, Taylor SC, Cox SE, Weinkle SH, Smith S, Kinney BM. Efficacy and safety of a new resilient hyaluronic acid dermal filler, in the correction of moderate-to-severe nasolabial folds. A 64-week, prospective, multicenter, controlled, randomized, doubleblind and within-subject study. J Cosmet Dermatol 2019 Oct;18(5):1244-1253. doi: 10.1111/jocd.13100.&#13;
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XXII.  Dayan S, Maas CS, Grimes PE, Beer K, Monheit G, Snow&#13;
S, Murphy DK, Lin V. Safety and effectiveness of VYC17.5L&#13;
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15;40(7):767-777. doi: 10.1093/asj/sjz200.&#13;
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ad.2010.01.004&#13;
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hydroxylapatite (Radiesse) for treatment of nasolabial&#13;
folds: long-term safety and efficacy results. Aesthet Surg&#13;
J 2010 Mar;30(2):235-8. doi: 10.1177/1090820X10366549. &#13;
Ferreira Pacheco de Oliveira CS, da Silva Almeida TJ, de&#13;
Oliveira-Martins L, Torelli Marques Sorpreso LA, Silveira&#13;
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Society and Development 2021;9(14):1-12. doi: 10.33448/&#13;
rsd-v10i14.21689.&#13;
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on safety and complications. J Cosmet Dermatol&#13;
2017;16(2):152-161. doi: 10.1111/jocd.12326.&#13;
VIII. Berlin A, Cohen JL, Goldberg DJ. Calcium hydroxylapatite&#13;
for facial rejuvenation. Semin Cutan Med Surg. 2006&#13;
Sep;25(3):132-7. doi: 10.1016/j.sder.2006.06.005.&#13;
IX. Tzikas TL. Evaluation of the Radiance FN soft tissue filler&#13;
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2004 Jul-Aug;6(4):234-9. doi: 10.1001/archfaci.6.4.234.&#13;
X. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA&#13;
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and meta-analyses: the PRISMA statement. PLoS Med&#13;
2009;6(7):e1000097. doi: 10.1371/journal.pmed.1000097.&#13;
XI. Narins RS, Beer K. Liquid injectable silicone: a review&#13;
of its history, immunology, technical considerations,&#13;
complications, and potential. Plast Reconstr&#13;
Surg 2006;118(3 Suppl):77S-84S. doi: 10.1097/01.&#13;
prs.0000234919.25096.67.&#13;
XII. Ahn MS. Calcium hydroxylapatite: Radiesse. Facial Plast&#13;
Surg Clin North Am 2007 Feb;15(1):85-90. doi: 10.1016/j.&#13;
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              <text>&lt;a href="https://lugoneseditorial.com.ar/novedades/dermatologia/acido-hialuronico-labios/"&gt;https://lugoneseditorial.com.ar/novedades/dermatologia/acido-hialuronico-labios/&lt;/a&gt;</text>
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                <text>Lip volumization with cross-linked hyaluronic acid 18 mg/ml. Efficacy and safety in 102 treated patients</text>
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                <text>Introduction: beauty trends have increased the demand for aesthetic procedures, especially the use of hyaluronic acid (HA), to rejuvenate the face and enhance lips. This safe and effective treatment hydrates, fills wrinkles, and restores volume to different areas of the face. HA is obtained from non-animal sources, is non-immunogenic, and possesses antioxidant properties. The perioral region, key to facial aging, is highly sought after for correcting wrinkles, folds, and the loss of definition caused by factors such as age, sun exposure, and lifestyle habits. Cross-linked hyaluronic acid (HRA) is an ideal option for restoring volume to this area.&#13;
&#13;
Objectives: to evaluate the safety, efficacy and adverse effects of using HRA 18 mg/ml as a lip filler. &#13;
&#13;
Materials and methods: a prospective clinical study included 102 patients (81 women and 21 men), aged 25–65, who required lip volumization and received Cientific Hyaluronic Facial Implant 18® (HRA 18 mg/ml). Treatment efficacy was assessed using the Global Aesthetic Improvement Scale (GAIS). Initial lip volume and perioral wrinkle severity were assessed using the photonumeric scales MERZ (Merz Lip Fullness Scale, MLFS) and Wrinkle Severity Rating Scale (WSRS), respectively. Safety was determined by analyzing local reactions at the injection site and the occurrence of adverse events. The product was administered at a dose of up to 1 ml per half of the lip in an initial application (T0), with follow-ups at 1, 3, and 8 months. If necessary, a single reapplication was performed during these follow-ups. Treatment efficacy was assessed at a final follow-up at 12 months. &#13;
&#13;
Results: adverse effects were mild, of immediate onset, common for this type of treatment, which resolved without the need for special treatment. The volumizing effect of HRA 18 mg/ml was effective in 98% of treated patients, with a gradual decrease after 12 months. A significant improvement in lip hydration and firmness was observed. &#13;
Conclusions: HRA 18 mg/ml is a safe and effective treatment as a dermal filler in lips, with high volume retention and lasting up to 12 months. Patients and professionals experienced high satisfaction, and improvements in skin firmness and elasticity were observed. The results support HRA as a viable and beneficial option in aesthetic medicine.</text>
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                <text>Claudio Dachevsky</text>
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            <name>Date</name>
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                <text>12/05/2025</text>
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                <text>&lt;a href="https://doi.org/10.47196/0595"&gt;https://doi.org/10.47196/0595&lt;/a&gt;</text>
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        <name>perioral area</name>
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              <text>&lt;a href="https://lugoneseditorial.com.ar/novedades/diabetes/monitoreo-continuo-de-glucosa/"&gt;https://lugoneseditorial.com.ar/novedades/diabetes/monitoreo-continuo-de-glucosa/&lt;/a&gt;</text>
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                <text>Monitoreo continuo de glucosa: nuevo portal de diabetes</text>
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            <name>Description</name>
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                <text>En el nuevo Portal Abbott Diabetes destacados especialistas dictan cursos certificados y on demand sobre los últimos avances en monitoreo continuo de glucosa y tecnología aplicada a la diabetes. Exclusivo para profesionales de la salud.</text>
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              <elementText elementTextId="248">
                <text>Lic. María Fernanda Cristoforetti, Editora de Lugones Editorial</text>
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            <name>Date</name>
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                <text>16 diciembre, 2024</text>
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                <text>Abbott Diabetes</text>
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        <name>Adrián Proietti</name>
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        <name>Alejandro Dain</name>
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        <name>Aspectos clave del uso del monitoreo continuo de glucosa</name>
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        <name>Florencia Siufi</name>
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